Photoredox-Catalyzed Addition of Dibromofluoromethane to Alkenes: Direct Synthesis of 1-Bromo-1-fluoroalkanes

Feng Chen, Xiu-Hua Xu and Feng-Ling Qing*

*Shanghai Institute of Organic Chemistry, University of Chinese Academy of Science, Chinese Academy of Science, 345 Lingling Lu, Shanghai 200032, China, Email: flqmail.sioc.ac.cn

F. Chen, X.-H. Xu, F.-L. Qing, Org. Lett., 2021, 23, 2364-2369.

DOI: 10.1021/acs.orglett.1c00639

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Abstract

The reaction of unactivated alkenes with dibromofluoromethane under photoredox catalysis provides 1-bromo-1-fluoroalkanes in THF as solvent. 1,3-Dibromo-1-fluoroalkanes were chemoselectively formed using DMF/H₂O as solvent.

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Key Words

fluoroalkanes, bromoalkanes, photochemistry

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ID: J54-Y2021