Iron-Catalyzed Diastereoselective Synthesis of Disubstituted Morpholines via C-O or C-N Bond Formation
Thomas Aubineau, Alexandre Dupas, Tian Zeng, Janine Cossy*
*Molecular, Macromolecular Chemistry and Materials, ESPCI
Paris, PSL University, CNRS, 10 Rue Vauquelin, 75005 Paris, France,
Email: janine.cossy
espci.fr
T. Aubineau, A. Dupas, T. Zeng, J. Cossy, J. An, Synlett, 2021, 32, 525-531.
DOI: 10.1055/s-0040-1707902
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Abstract
Iron(III) catalyzes a diastereoselective synthesis of 2,6- and 3,5-disubstituted morpholines from 1,2-amino ethers and 1,2-hydroxy amines substituted by an allylic alcohol. The morpholines were obtained either by C-O or C-N bond formation.
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Key Words
morpholines, iron, diastereoselective, thermodynamic equilibrium
ID: J72-Y2021
