Photocatalytic Dehydroxymethylative Arylation by Synergistic Cerium and Nickel Catalysis

Yuegang Chen, Xin Wang, Xu He, Qing An and Zhiwei Zuo*

*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China, Email: zuozhwsioc.ac.cn

Y. Chen, X. Wang, X. He, Q. An, Z. Zuo, J. Am. Chem. Soc., 2021, 143, 4896-4902.

DOI: 10.1021/jacs.1c00618

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Abstract

The combination of inexpensive cerium and nickel catalysts enables the use of easily accessible free alcohols as operationally simple and robust carbon pronucleophiles in selective C(sp³)-C(sp²) cross-couplings with the extrusion of formaldehyde. A broad range of free alcohols and aromatic halides can be employed in this transformation.

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proposed mechanism

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Key Words

diarylmethanes, pyrrolidines, photochemistry

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ID: J48-Y2021