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Pd-Catalyzed Assembly of Fluoren-9-ones by Merging of CH Activation and Difluorocarbene Transfer

Xiaobing Liu, Heyun Sheng, Yao Zhou and Qiuling Song*

*College of Materials Science & Engineering and College of Chemical Engineering at Huaqiao University, 668 Jimei Boulevard, Xiamen 361021, Fujian, P. R. China, Email: qsonghqu.edu.cn

X. Liu, H. Sheng, Y. Zhou, Q. Song, Org. Lett., 2021, 23, 2543-2547.

DOI: 10.1021/acs.orglett.1c00467


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Abstract

ClCF2COONa serves as a coupling partner in a Pd-catalyzed assembly of fluoren-9-ones by merging of C-H activation and difluorocarbene transfer. The current protocol provides fluoren-9-ones in high yields with excellent functional group compatibility.


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proposed mechanism



Key Words

fluoren-9-ones


ID: J54-Y2021