Palladium-Catalyzed Regioselective C-H Functionalization/Annulation Reaction of Amides and Allylbenzenes for the Synthesis of Isoquinolinones and Pyridinones
Rong Zhong, Yong Xu, Manman Sun* and Yurong Wang*
*Taizhou University, 1139 Shifu Avenue, Taizhou 318000; Zhejiang Chinese Medical University, Hangzhou 310053, P. R. China, Email: sunmmtzc.edu.cn, yrwang1024hotmail.com
R. Zhong, Y. Xu, M. Sun, Y. Wang, J. Org. Chem., 2021, 86, 5255-5264.
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A palladium-catalyzed C(sp2)-H allylation/aminopalladation/β-H elimination/isomerization sequence enables an annulation reaction of N-sulfonyl amides and allylbenzenes to construct isoquinolinones and pyridinones in good yield in the presence of air as the terminal oxidant.
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