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Radical Decarboxylative Carbometalation of Benzoic Acids: A Solution to Aromatic Decarboxylative Fluorination

Peng Xu, Priscila López-Rojas and Tobias Ritter*

*Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm Platz 1, D-45470 Mülheim an der Ruhr, Germany, Email:

P. Xu, P. López-Rojas, T. Ritter, J. Am. Chem. Soc., 2021, 143, 5349-5354.

DOI: 10.1021/jacs.1c02490


A low-barrier photoinduced ligand to metal charge transfer (LMCT) enables a radical decarboxylative carbometalation strategy. Formation of a putative high-valent arylcopper(III) complex facilitates reductive eliminations to occur. This approach is suitable to address a previously unrealized general decarboxylative fluorination of benzoic acids at low temperature.

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proposed mechanism

Key Words

Fluorination, Decarboxylation, Photochemistry, Copper

ID: J48-Y2021