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Palladium(II)-Catalyzed Three-Component Tandem Cyclization Reaction for the One-Pot Assembly of 4-Arylquinazolines

Zijuan Wang, Wenteng Chen, Chang He, Guolin Zhang*, Yongping Yu*

*College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Zijin Campus, Hangzhou 310058, P. R. of China, Email:,

Z. Wang, W. Chen, C. He, G. Zhang, Y. Yu, Synthesis, 2021, 53, 1356-1364.

DOI: 10.1055/s-0040-1707329

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A palladium(II)-catalyzed­ cascade reaction of 2-aminobenzonitriles with triethyl orthocarboxylates and boronic acids provides 4-arylquinazolines in good yields. The method involves C(sp)-C(sp2) coupling followed by intramolecular C-N bond formation. The reaction was readily scaled up to gram quantity.

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Key Words

quinazolines, palladium(II) catalysis, multicomponent reactions, tandem cyclization reaction, ligands

ID: J66-Y2021