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Copper and N-Heterocyclic Carbene-Catalyzed Oxidative Amidation of Aldehydes with Amines

Ashmita Singh, Anudeep Kumar Narula*

*University School of Basic and Applied Sciences, Guru Gobind Singh, Indraprastha University, Sector-16C Dwarka, New Delhi-110078, India, Email:

A. Singh, A. K. Narula, Synlett, 2021, 32, 718-722.

DOI: 10.1055/a-1343-5203


The combination of copper(I) iodide and an N-heterocyclic carbene catalyzes an oxidative amidation of aldehydes with amines in the presence of tert-butyl hydroperoxide. The method is simple and practicable, has a broad substrate scope, and uses economical, feasible, and abundant reagents.

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Key Words

N-heterocyclic carbenes, copper catalysis, tert-butyl hydroperoxide, aldehydes, amines, oxidative amidation

ID: J72-Y2021