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Saegusa Oxidation of Enol Ethers at Extremely Low Pd-Catalyst Loadings under Ligand-free and Aqueous Conditions: Insight into the Pd(II)/Cu(II)-Catalyst System

Quan Zhu, Yunsong Luo, Yongyan Guo, Yushun Zhang and Yunhai Tao*

*School of Chemical Science and Technology, Yunnan University, Kunming 650091, PR China, Email:

Q. Zhu, Y. Luo, Y. Guo, Y. Zhang, Y. Tao, J. Org. Chem., 2021, 86, 5463-5476.

DOI: 10.1021/acs.joc.0c02987

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A highly efficient and practical Pd(II)/Cu(OAc)2 catalyzed Saegusa oxidation converts enol ethers to the corresponding enals at extremely low catalyst loadings under ligand-free and aqueous conditions. Its synthetic utility was demonstrated with a number of diverse substrates and large-scale applications.

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Key Words

enals, copper(II)

ID: J42-Y2021