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Cu-Catalyzed Oxidative Allylic C-H Arylation of Inexpensive Alkenes with (Hetero)Aryl Boronic Acids

Suman Pal, Marine Cotard, Baptiste Gérardin, Christophe Hoarau* and Cédric Schneider*

*Normandy University, University of Rouen, INSA Rouen, CNRS, COBRA UMR 6014, 1 rue Tesnière, 76821 Mont-Saint Aignan Cedex, France, Email:,

S. Pal, M. Cotard, B. Gérardin, C. Hoarau, C. Schneider, Org. Lett., 2021, 23, 3130-3135.

DOI: 10.1021/acs.orglett.1c00812

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A regioselective oxidative allylic C(sp3)-H arylation of readily available unactivated terminal and internal olefins with a broad range of heteroaryl boronic acids is catalyzed by cheap, abundant, and nontoxic Cu2O. This method does not require traditional coupling partners with preinstalled leaving groups at the allylic position, thus offering an alternative method to allylic arylation.

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Key Words

allylation, cyclohexenes, cycloheptenes, DTBP

ID: J54-Y2021