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Regioselective Three-Component Synthesis of Vicinal Diamines via 1,2-Diamination of Styrenes

Jie Cao, Daqi Lv, Fei Yu, Mong-Feng Chiou, Yajun Li and Hongli Bao*

*Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yangqiao Road West, Fuzhou, Fujian 350002, P. R. China, Email:

J. Cao, D. Lv, F. Yu, M.-F. Chiou, Y. Li, H. Bao, Org. Lett., 2021, 23, 3184-3189.

DOI: 10.1021/acs.orglett.1c00898

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A regioselective intermolecular three-component reaction of styrenes with acetonitrile and azodicarboxylates provides vicinal diamination products in good yields via the Ritter reaction.

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proposed mechanism

Key Words

diamines, hydrazines, Ritter Reaction, multicomponent reactions

ID: J54-Y2021