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Nickel(II)- and Silver(I)-Catalyzed C-H Bond Halogenation of Anilides and Carbamates

Ebrahim Kianmehr*, Hadi Afaridoun

*School of Chemistry, College of Science,University of Tehran, Tehran 1417614411, Iran, Email: kianmehrkhayam.ut.ac.ir

E. Kianmehr, H. Afaridoun, Synthesis, 2021, 53, 1513-1523.

DOI: 10.1055/s-0040-1705972 (free Supporting Information)


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Abstract

Silver carbonate or nickel(II) chloride catalyzes an ortho-C-H bond halogenation of anilides and N-aryl carbamates with N-halosuccinimides to provide 2-haloanilides and carbamates, which may serve as starting materials for the synthesis of pharmaceutically and biologically active compounds.

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Key Words

cross-coupling reactions, C-H activation, homogeneous catalysis, bromination, chlorination, iodination, nickel, silver, NBS, NCS, NIS


ID: J66-Y2021