Deoxyfluorination of Carboxylic Acids with KF and Highly Electron-Deficient Fluoroarenes

Siyu Mao, Jordan H. Kramer and Haoran Sun*

*Department of Chemistry & Center for Fluorinated Functional Materials, University of South Dakota, Vermillion, South Dakota 57069, United States, Email: Haoran.Sunusd.edu

S. Mao, J. H. Kramer, H. Sun, J. Org. Chem., 2021, 86, 6066-6074.

DOI: 10.1021/acs.joc.0c02491

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Abstract

A deoxyfluorination reaction of carboxylic acids using potassium fluoride (KF) and highly electron-deficient fluoroarenes provides acyl fluorides good yields.

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proposed mechanism

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Key Words

acyl fluorides

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ID: J42-Y2021