Nickel-Catalyzed Intramolecular Nucleophilic Addition of Aryl Halides to Aryl Ketones for the Synthesis of Benzofuran Derivatives
Xiao-Rui Zhu, Chen-Liang Deng*
*College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. of China,
Email: dcl78
wzu.edu.cn
X.-R. Zhu, C.-L. Deng, Synthesis, 2021, 53, 1842-1848.
see article for more reactions
Abstract
A nickel-catalyzed intramolecular nucleophilic addition reaction of aryl halides to aryl ketones provides benzofuran derivatives in moderate yields. A number of substrates bearing electron-donating or electron-withdrawing groups can be converted.
see article for more examples
Key Words
nickel, zinc powder, intramolecular addition, cyclization, benzofurans
ID: J66-Y2021
