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I2-Catalyzed Three-Component Consecutive Reaction for the Synthesis of 3-Aroylimidazo[1,2-a]-N-Heterocycles

Yi Zhang, Rener Chen, Zhiming Wang, Lei Wang and Yongmin Ma*

*Institute of Advanced Studies and School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou 318000, P. R. China, Email:

Y. Zhang, R. Chen, Z. Wang, L. Wang, Y. Ma, J. Org. Chem., 2021, 86, 6239-6246.

DOI: 10.1021/acs.joc.1c00023

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A convenient one-pot, three-component reaction of aryl ketones with 2-amino-N-heterocycles and dimethyl sulfoxide as a methylene donor provides 3-aroylimidazo[1,2-a]-N-heterocycles in good yields in the presence of K2S2O8 and a catalytic amount of I2.

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proposed mechanism

Key Words

imidazo[1,2-a]pyridines, potassium peroxydisulfate, multicomponent reactions

ID: J42-Y2021