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Construction of α-Alkylated Amines by Iridium Complex-Catalyzed One-Step Transfer Hydrogenation of C=C and C=N Bonds

Yanping Xia, Lu Ouyang, Jianhua Liao, Xiao Yang, Renshi Luo*

*School of Pharmacy, Gannan Medical University, Ganzhou 341000, Jiangxi Province, P. R. of China, Email:

Y. Xia, L. Ouyang, J. Liao, X. Yang, R. Luo, Synthesis, 2021, 53, 1821-1827.

DOI: 10.1055/a-1344-2126

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An iridium complex catalyzes an environmentally friendly, efficient, and facile one-pot transfer hydrogenation of C=C bond of enones and reductive amination of C=N bond of imines in the presence of formic acid as hydrogen source in aqueous medium. This reaction provides a wide range of α-alkylated amines in excellent yield.

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Key Words

transfer hydrogenation, formic acid, iridium complex, reductive amination, 1,4-reduction, enones

ID: J66-Y2021