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[(PPh3)2NiCl2]-Catalyzed C-N Bond Formation Reaction via Borrowing Hydrogen Strategy: Access to Diverse Secondary Amines and Quinolines

S. N. R. Donthireddy, Vipin K. Pandey and Arnab Rit*

*Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India, Email: arnabritiitm.ac.in

S. N. R. Donthireddy, V. K. Pandey, A. Rit, J. Org. Chem., 2021, 86, 6994-7001.

DOI: 10.1021/acs.joc.1c00510 (free Supporting Information)


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Abstract

Commercially available [(PPh3)2NiCl2] is an efficient catalyst for the mono-N-alkylation of (hetero)aromatic amines, employing alcohols to deliver diverse secondary amines in excellent yields via the borrowing hydrogen strategy. The catalyst system can also be used for accessing various quinoline derivatives following the acceptorless dehydrogenation pathway.

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Key Words

benzylamines, arylamines


ID: J42-Y2021