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Controllable Lewis Base Catalyzed Michael Addition of α-Amino­nitriles to Activated Alkenes: Facile Synthesis of Functionalized γ-Amino Acid Esters and γ-Lactams

Ze-Ying He, Ho-Chol Jang, Le-Sheng Teng, Zhong-Lin Wei*, Wei-Wei Liao*

*Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. of China, Email:,

Z.-Y. He, H.-C. Jang, L.-S. Teng, Z.-L. Wei, W.-W. Liao, Synthesis, 2021, 53, 1833-1841.

DOI: 10.1055/a-1337-4684

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Depending on the Lewis base catalyst, a Michael addition of α-aminonitriles to simple activated alkenes provides functionalized γ-amino acid esters or γ-lactams. The scope, versatility, and efficiency of the methods were demonstrated.

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Key Words

Lewis base, organocatalysis, Michael addition, α-amino nitriles, γ-amino acid derivatives, γ-lactams

ID: J66-Y2021