Asymmetric Reduction of Aromatic α-Dehydroamino Acid Esters with Water as Hydrogen Source
Yuze Dai, Jingchao Chen*, Zheting Wang, Ting Wang, Lin Wang, Yong Yang, Xingfang Qiao and Baomin Fan*
*Yunnan Minzu University, Kunming 650504, Yunnan, China, Email: chenjingchao84163.com, adams.bmfhotmail.com
Y. Dai, J. Chen, Z. Wang, T. Wang, L. Wang, Y. Yang, X. Qiao, B. Fan, J. Org. Chem., 2021, 86, 7141-7147.
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A Rh/Cu co-catalytic system enables an asymmetric reduction of aromatic α-dehydroamino acid esters with water as the hydrogen source to provide chiral α-amino acid esters. The reaction tolerates various functional groups and provides access to chiral deuterated α-amino esters by using D2O.
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reduction of allkenes, reduction of α,β-unsaturated compounds, reduction of enamines, zinc