Manganese-Mediated Direct Functionalization of Hantzsch Esters with Alkyl Iodides via an Aromatization-Dearomatization Strategy
Xian-Guan Liu, Ci-Shuang Dong, Fei Li* and Bo Zhang*
*State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China,
Email: lifei
cpu.edu.cn, zb3981444cpu.edu.cn
X.-G. Liu, C.-S. Dong, F. Li, B. Zhang, Org. Lett., 2021, 23, 4002-4007.
DOI: 10.1021/acs.orglett.1c01210
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Abstract
Manganese mediates a direct functionalization of Hantzsch esters with readily accessible alkyl iodides through an aromatization–dearomatization strategy to provide valuable 4-alkyl-1,4-dihydropyridines in good yields under visible-light irradiation at room temperature. The reacton displays high functional-group compatibility and is applicable for gram-scale synthesis and late-stage functionalization.
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proposed mechanism
Key Words
ID: J54-Y2021
