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Highly Regio- and Enantioselective Reductive Coupling of Alkynes and Aldehydes via Photoredox Cobalt Dual Catalysis

Yan-Lin Li, Shi-Qi Zhang, Jie Chen and Ji-Bao Xia*

*Center for Excellence in Molecular Synthesis, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China, Email:

Y.-L. Li, S.-Q. Zhang, J. Chen, J.-B. Xia, J. Am. Chem. Soc., 2021, 143, 7306-7313.

DOI: 10.1021/jacs.1c03527

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The combination of a chiral Co complex and a photocatalyst mediates a highly regio- and enantioselective reductive coupling of internal alkynes with aldehydes to provide enantioenriched allylic alcohols in excellent regio-, stereo-, and enantioselectivity. The method offers mild reaction conditions, broad substrate scope, and good functional group compatibility.

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Ligand, photocatalyst and reductant

Key Words

allylic alcohols, photochemistry, Hantzsch ester

ID: J48-Y2021