Highly Regio- and Enantioselective Reductive Coupling of Alkynes and Aldehydes via Photoredox Cobalt Dual Catalysis
Yan-Lin Li, Shi-Qi Zhang, Jie Chen and Ji-Bao Xia*
*Center for Excellence in Molecular Synthesis, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China,
Email: jibaoxia
licp.cas.cn
Y.-L. Li, S.-Q. Zhang, J. Chen, J.-B. Xia, J. Am. Chem. Soc., 2021, 143, 7306-7313.
DOI: 10.1021/jacs.1c03527
see article for more reactions
Abstract
The combination of a chiral Co complex and a photocatalyst mediates a highly regio- and enantioselective reductive coupling of internal alkynes with aldehydes to provide enantioenriched allylic alcohols in excellent regio-, stereo-, and enantioselectivity. The method offers mild reaction conditions, broad substrate scope, and good functional group compatibility.
see article for more examples
Ligand, photocatalyst and reductant
Key Words
allylic alcohols, photochemistry, Hantzsch ester
ID: J48-Y2021
