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Pd-Catalyzed Enantioselective Dicarbofunctionalization of Alkene to Access Disubstituted Dihydroisoquinolinone

Qiaoyu Chen, Sanliang Li, Xiaoxiao Xie, Hao Guo*, Junfeng Yang* and Junliang Zhang*

*Department of Chemistry, Fudan University, 2005 Songhu Road, Shanghai, 200438, China, Email:,,

Q. Chen. S. Li, X. Xie, H. Guo, J. Yang, J. Zhang, Org. Lett., 2021, 23, 4099-4103.

DOI: 10.1021/acs.orglett.1c00974

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A Pd/Xu-Phos-catalyzed asymmetric Heck/Suzuki domino reaction enables the synthesis of chiral disubstituted dihydroisoquinolinones in good yields and excellent enantioselectivities. The reaction shows high functional group tolerance and enables coupling with various aryl/alkenyl boronates.

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Key Words


ID: J54-Y2021