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Rhodium-Catalyzed Regio- and Enantioselective Allylic Amination of Racemic 1,2-Disubstituted Allylic Phosphates

Wen-Bin Xu, Minghe Sun, Mouhai Shu and Changkun Li*

*School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China, Email:

W.-B. Xu, M. Sun, M. Shu, C. Li, J. Am. Chem. Soc., 2021, 143, 8255-8260.

DOI: 10.1021/jacs.1c04016

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Chiral bis(oxazoline)alkynylphosphine ligands can be used in Rh-catalyzed highly regio- and enantioselective allylic amination reactions of racemic 1,2-disubstituted allylic phosphates to provide chiral 1,2-disubstituted allylic amines in very good yield with >20:1 branched/linear ratio and excellent ee.

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Key Words

allylic amines

ID: J48-Y2021