Asymmetric Synthesis of Protected Unnatural α-Amino Acids via Enantioconvergent Nickel-Catalyzed Cross-Coupling
Ze-Peng Yang, Dylan J. Freas and Gregory C. Fu*
*Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States,
Email: gcfu
caltech.edu
Z.-P. Yang, D. J. Freas, G. C. Fu, J. Am. Chem. Soc., 2021, 143, 8614-8618.
DOI: 10.1021/jacs.1c03903
see article for more reactions
Abstract
A chiral catalyst based on nickel, an earth-abundant metal, can achieve the enantioconvergent coupling of readily available racemic alkyl electrophiles with a wide variety of alkylzinc reagents to afford protected unnatural α-amino acids in good yield and ee. This cross-coupling proceeds under mild conditions and is tolerant of air, moisture, and a broad array of functional groups.
see article for more examples
Key Words
ID: J48-Y2021
