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Ni-Catalyzed Reductive Allylation of α-Chloroboronates to Access Homoallylic Boronates

Yixian Lou, Jian Qiu, Kai Yang, Feng Zhang, Chenglan Wang and Qiuling Song*

*Institute of Next Generation Matter Transformation, College of Materials Science Engineering at Huaqiao University, Xiamen, Fujian 361021, China, Email:

Y. Lou, J. Qiu, K. Yang, F. Zhang, C. Wang, Q. Song, Org. Lett., 2021, 23, 4564-4569.

DOI: 10.1021/acs.orglett.1c01213

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A Ni-catalyzed reductive allylation of α-chloroboronates with allyl sulfones efficiently provides the corresponding homoallylic boronates, which could be readily converted into valuable homoallylic alcohols or amines or 1,4-diboronates. This reaction features a broad substrate scope with good functional group compatibility.

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proposed mechanisms

Key Words

allylation, boronates, zinc

ID: J54-Y2021