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Mild and Efficient Copper-Catalyzed Synthesis of Trisubstituted Pyrroles

Ming-Hua Hsu*, Mohit Kapoor, Tapan Kumar Pradhan, Man-Him Tse, Hsin-Ya Chen, Man-Jun Yan, Yu-Tsen Cheng, Yu-Cheng Lin, Cheng-Ying Hsieh, Ker-Yin Liu, Chien-Chung Han

*Department of Chemistry, National Changhua University of Education, Changhua 50007, Taiwan, Email:

M.-H. Hsu, M. Kapoor, T. K. Pradhan, M.-H. Tse, H.-Y. Chen, M.-J. Yan, Y.-T. Cheng, Y.-C. Lin, C.-Y. Hsieh, K.-Y. Liu, C.-C. Han, Synthesis, 2021, 53, 2212-2218.

DOI: 10.1055/a-1331-7346 (free Supporting Information)

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Copper iodide catalyzes a sustainable and time economic synthesis of polysubstituted pyrroles in excellent yields with high regioselectivity under mild conditions. The reaction proceedes through imine formation followed by cyclization with an alkyne-Cu intermediate.

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Key Words

copper, Cu-catalyzed, pyrroles, cyclization, multicomponent reactions

ID: J66-Y2021