Mild and Efficient Copper-Catalyzed Synthesis of Trisubstituted Pyrroles
Ming-Hua Hsu*, Mohit Kapoor, Tapan Kumar Pradhan, Man-Him Tse, Hsin-Ya Chen, Man-Jun Yan, Yu-Tsen Cheng, Yu-Cheng Lin, Cheng-Ying Hsieh, Ker-Yin Liu, Chien-Chung Han
*Department of Chemistry, National Changhua University of Education, Changhua 50007, Taiwan, Email: minghuahsucc.ncue.edu.tw
M.-H. Hsu, M. Kapoor, T. K. Pradhan, M.-H. Tse, H.-Y. Chen, M.-J. Yan, Y.-T. Cheng, Y.-C. Lin, C.-Y. Hsieh, K.-Y. Liu, C.-C. Han, Synthesis, 2021, 53, 2212-2218.
DOI: 10.1055/a-1331-7346
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Abstract
Copper iodide catalyzes a sustainable and time economic synthesis of polysubstituted pyrroles in excellent yields with high regioselectivity under mild conditions. The reaction proceedes through imine formation followed by cyclization with an alkyne-Cu intermediate.
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Key Words
copper, Cu-catalyzed, pyrroles, cyclization, multicomponent reactions
ID: J66-Y2021