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FeCl2-Mediated Regioselective Aminochlorination and Aminoazidation of Styrenes with Trifluoromethanesulfonyl Azide

Jing Zhao, Hong-Gui Huang, Weishuang Li and Wen-Bo Liu*

*College of Chemistry and Molecular Sciences, Wuhan University. 299 Bayi Road, Wuhan, Hubei 430072, China, Email:

J. Zhao, H.-G. Huang, W. Li, W.-B. Liu, Org. Lett., 2021, 23, 5102-5106.

DOI: 10.1021/acs.orglett.1c01642

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The use of N3SO2CF3 as an amination reagent and FeCl2 as a chloride source enables an efficient aminochlorination reaction of stryenes . The operationally simple procedure offers mild reaction conditions, good functional group compatibility, and high regioselectivity. Aminobromination using FeBr2 and a one-pot aminoazidation of styrenes are also realized.

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Key Words


ID: J54-Y2021