Synthetic Route to Enaminones via Metal-Free Four-Component Sequential Reactions of Aryl Olefins with CHCl₃, Et₃N, and TBHP

Jiantao Zhang, Peng Zhou, Aiguo Yin, Shuhua Zhang and Weibing Liu

*Guangdong University of Petrochemical Technology, Guandu Road, Maoming 525000, P. R. China, Email: yinlife8hotmail.com, lwb409gdupt.edu.cn

J. Zhang, P. Zhou, A. Yin, S. Zhang, W. Liu, J. Org. Chem., 2021, 86, 8980-8986.

DOI: 10.1021/acs.joc.1c00823

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Abstract

An efficient and modular strategy based on a four-component sequential reaction provides enaminones under mild conditions without a catalyst in one pot. Furthermore, the products could be transformed into thiadiazoles.

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proposed mechanism

Key Words

enaminones (olefination, amination), TBHP, multicomponent reactions

ID: J42-Y2021

Synthetic Route to Enaminones via Metal-Free Four-Component Sequential Reactions of Aryl Olefins with CHCl3, Et3N, and TBHP

Jiantao Zhang, Peng Zhou, Aiguo Yin*, Shuhua Zhang and Weibing Liu*

Synthetic Route to Enaminones via Metal-Free Four-Component Sequential Reactions of Aryl Olefins with CHCl₃, Et₃N, and TBHP

Jiantao Zhang, Peng Zhou, Aiguo Yin, Shuhua Zhang and Weibing Liu