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Palladium-Catalyzed C-P(III) Bond Formation by Coupling ArBr/ArOTf with Acylphosphines

Xingyu Chen, Hongyu Wu, Rongrong Yu, Hong Zhu* and Zhiqian Wang*

*Department of Organic Chemistry, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, China, Email: zhuho128126.com, wangzhqmail.buct.edu.cn

X. Chen, H. Wu, R. Yu, H. Zhu, Z. Wang, J. Org. Chem., 2021, 86, 8987-8996.

DOI: 10.1021/acs.joc.1c00937



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Abstract

Acylphosphines are inert to air and moisture. A palladium-catalyzed C-P bond formation reaction using acylphosphines as phosphination reagents shows practicable reactivity with ArBr and ArOTf to afford trivalent phosphines directly in good yields with a broad substrate scope and functional group tolerance.

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proposed mechanism



Key Words

phosphines


ID: J42-Y2021