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Copper-Catalyzed Coupling of Amines with Carbazates: An Approach to Carbamates

Song-Ning Wang, Guo-Yu Zhang, Adedamola Shoberu and Jian-Ping Zou*

*Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Soochow University, 199 Renai Street, Suzhou, Jiangsu 215123, China, Email:

S.-N. Wang, G.-Y. Zhang, A. Shoberu, J.-P. Zou, J. Org. Chem., 2021, 86, 9067-9075.

DOI: 10.1021/acs.joc.1c01031

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A copper-catalyzed cross-coupling reaction of amines with alkoxycarbonyl radicals generated from carbazates provides carbamates under mild conditions. This environmentally friendly approach is compatible with a wide range of amines, including aromatic/aliphatic and primary/secondary substrates.

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proposed mechanism

Key Words

carbamates, TBHP

ID: J42-Y2021