Base-Catalyzed Three-Component Reaction between Chalcones, Isothiocyanates, and Sulfur: Access to Thiazole-2-thiones
Thanh Binh Nguyen* and Pascal Retailleau
*Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud, Université Paris-Saclay, 1 avenue de la Terrasse, 91198 Gif-sur-Yvette, France,
Email: thanh-binh.nguyen
cnrs.fr
T. B. Nguyen, P. Retailleau, Org. Lett., 2021, 23, 5344-5348.
DOI: 10.1021/acs.orglett.1c01653
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Abstract
A convenient base-catalyzed three-component reaction between chalcones, isothiocyanates, and elemental sulfur provides thiazole-2-thiones in very good yields.
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proposed mechanism
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Key Words
thiazole-2-thiones, multicomponent reactions
ID: J54-Y2021
