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Base-Catalyzed Three-Component Reaction between Chalcones, Isothiocyanates, and Sulfur: Access to Thiazole-2-thiones

Thanh Binh Nguyen* and Pascal Retailleau

*Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud, Université Paris-Saclay, 1 avenue de la Terrasse, 91198 Gif-sur-Yvette, France, Email: thanh-binh.nguyencnrs.fr

T. B. Nguyen, P. Retailleau, Org. Lett., 2021, 23, 5344-5348.

DOI: 10.1021/acs.orglett.1c01653 (free Supporting Information)


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Abstract

A convenient base-catalyzed three-component reaction between chalcones, isothiocyanates, and elemental sulfur provides thiazole-2-thiones in very good yields.

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proposed mechanism



Key Words

N-heterocycles, S-heterocycles, multicomponent reactions


ID: J54-Y2021