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Copper-Catalyzed Enaminone C(sp2)-N Bond Phosphonation for Stereoselective Synthesis of Alkenylphosphonates

Ting Liu, Li Wei, Baoli Zhao, Yunyun Liu* and Jie-Ping Wan*

*College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, People's Republic of China, Email:,

T. Liu, L. Wei, B. Zhao, Y. Liu, J.-P. Wan, J. Org. Chem., 2021, 86, 9861-9868.

DOI: 10.1021/acs.joc.1c00862 (free Supporting Information)


A direct enaminone C-N bond coupling with dialkyl phosphonate enables a stereoselective synthesis of (E)-alkenylphosphonates with a broad scope.

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proposed mechanism

Key Words


ID: J42-Y2021