Copper-Catalyzed Enaminone C(sp²)-N Bond Phosphonation for Stereoselective Synthesis of Alkenylphosphonates

Ting Liu, Li Wei, Baoli Zhao, Yunyun Liu* and Jie-Ping Wan*

*College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, People's Republic of China, Email: chemliuyunyunjxnu.edu.cn, wanjiepingjxnu.edu.cn

T. Liu, L. Wei, B. Zhao, Y. Liu, J.-P. Wan, J. Org. Chem., 2021, 86, 9861-9868.

DOI: 10.1021/acs.joc.1c00862

---

Abstract

A direct enaminone C-N bond coupling with dialkyl phosphonate enables a stereoselective synthesis of (E)-alkenylphosphonates with a broad scope.

see article for more examples

proposed mechanism

---

---

Key Words

phosphonates

---

ID: J42-Y2021