Direct C(sp³)-H Cyanation Enabled by a Highly Active Decatungstate Photocatalyst

Kunsoon Kim, Seulchan Lee and Soon Hyeok Hong*

*Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea, Email: soonhyeok.hongkaist.ac.kr

K. Kim, S. Lee, S. H. Hong, Org. Lett., 2021, 23, 5501-5505.

DOI: 10.1021/acs.orglett.1c01846

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Abstract

A highly efficient, direct C(sp³)-H cyanation under mild photocatalytic conditions offers excellent functional group tolerance. Notably, complex natural products and bioactive compounds were efficiently cyanated.

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proposed mechanism

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Key Words

cyanohydrins, aminonitriles, photochemistry

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ID: J54-Y2021