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Scalable Synthetic Strategy for Unsymmetrical Trisubstituted s-Triazines

Helong Liang, Ganzhong Li, Lei Zhang, Gefei Wang, Mingyu Song, Heng Li and Bingxin Yuan*

*Green Catalysis Center, College of Chemistry, Zhengzhou University, Zhengzhou, Henan 450001, China, Email:

H. Liang, G. Li, L. Zhang, G. Wang, M. Song, H. Li, B. Yuan, Org. Lett., 2021, 23, 5821-5825.

DOI: 10.1021/acs.orglett.1c01970

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The reaction of in situ formed acyl isocyanates with amidines provides disubstituted 1,3,5-triazinones with a low production cost and a simple workup procedure. Chlorination and a further coupling reaction with various nucleophiles gives unsymmetrical trisubstituted 1,3,5-triazines bearing diverse functional groups.

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Chlorination of 1,3,5-Triazin-2(1H)-ones

Key Words

1,3,5-Triazin-2(1H)-ones, N-Heterocycles

ID: J54-Y2021