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Visible-Light-Induced C-H Bond Aminoalkylation of Heterocycles by the Decarboxylation Coupling of Amino Acids

Yifan Li, Changhui Dai, Shentong Xie, Ping Liu* and Peipei Sun*

*School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China, Email: pingliunjnu.edu.cn, sunpeipeinjnu.edu.cn

Y. Li, C. Dai, S. Xie, P. Liu, P. Sun, Org. Lett., 2021, 23, 5906-5910.

DOI: 10.1021/acs.orglett.1c02014 (free Supporting Information)


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Abstract

An efficient visible-light-induced decarboxylative coupling reaction of N-protected α-amino acids with heterocycles provides aminoalkylated heterocycles in good yields. Attractive features of this process include the generation of aminomethyl radical by an inexpensive organic photocatalyst under transition-metal-free conditions.

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Key Words

Quinoxalinones, Organocatalysis, Photochemistry


ID: J54-Y2021