Copper-Catalyzed Synthesis of 5-Carboxyl-4-perfluoroalkyl Triazoles
Robert Panish*, Tho Thieu and Jaume Balsells
*Discovery Process Research, Janssen R&D, 1400 McKean Road, Spring House, Pennsylvania 19477, United States, Email: rpanishits.jnj.com
R. Panish, T. Thieu, J. Balsells, Org. Lett., 2021, 23, 5937-5941.
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Copper catalyzes a rapid assembly of 5-carboxyl-4-perfluoroalkyl-triazoles from N-tosylhydrazides and perfluoroalkyl acetoacetates. The approach exhibits high functional group tolerance and can be executed on a multigram scale.
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