Organic Chemistry Portal



Copper-Catalyzed Synthesis of 5-Carboxyl-4-perfluoroalkyl Triazoles

Robert Panish*, Tho Thieu and Jaume Balsells

*Discovery Process Research, Janssen R&D, 1400 McKean Road, Spring House, Pennsylvania 19477, United States, Email:

R. Panish, T. Thieu, J. Balsells, Org. Lett., 2021, 23, 5937-5941.

DOI: 10.1021/acs.orglett.1c02037

see article for more reactions


Copper catalyzes a rapid assembly of 5-carboxyl-4-perfluoroalkyl-triazoles from N-tosylhydrazides and perfluoroalkyl acetoacetates. The approach exhibits high functional group tolerance and can be executed on a multigram scale.

see article for more example

Key Words

1,2,3-triazoles, DMSO

ID: J54-Y2021