Merging C-H Activation and Strain-Release in Ruthenium-Catalyzed Isoindolinone Synthesis
Xiao-Qiang Hu*, Zi-Kui Liu, Ye-Xing Hou, Ji-Hang Xu and Yang Gao*
*South-Central University for Nationalities, Wuhan 430074; Guangdong University of Technology, Guangzhou, 510006, China,
Email: huxiaoqiang
mail.scuec.edu.cn; gaoyanggdut.edu.cn
X.-Q. Hu, Z.-K. Liu, Y.-X. Hou, J.-H. Xu, Y. Gao, Org. Lett., 2021, 23, 6332-6336.
DOI: 10.1021/acs.orglett.1c02131
see article for more reactions
Abstract
The merger of strain-release of 1,2-oxazetidines with carboxylic acid directed C-H activation enables a catalytic synthesis of a range of structurally diverse isoindolinones from readily available benzoic acids.
see article for more example
proposed mechanism
Key Words
ID: J54-Y2021
