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Merging C-H Activation and Strain-Release in Ruthenium-Catalyzed Isoindolinone Synthesis

Xiao-Qiang Hu*, Zi-Kui Liu, Ye-Xing Hou, Ji-Hang Xu and Yang Gao*

*South-Central University for Nationalities, Wuhan 430074; Guangdong University of Technology, Guangzhou, 510006, China, Email:;

X.-Q. Hu, Z.-K. Liu, Y.-X. Hou, J.-H. Xu, Y. Gao, Org. Lett., 2021, 23, 6332-6336.

DOI: 10.1021/acs.orglett.1c02131

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The merger of strain-release of 1,2-oxazetidines with carboxylic acid directed C-H activation enables a catalytic synthesis of a range of structurally diverse isoindolinones from readily available benzoic acids.

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proposed mechanism

Key Words


ID: J54-Y2021