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Yb(OTf)3-Mediated Regioselective Hydroamination of Ynamides with Anilines and p-Toluenesulfonamide

Xiaobao Zeng*, Qingyun Gu, Wenjing Dai, Yushan Xie, Xinyi Liu, Guixia Wu

*Department of Chemistry, National Changhua University of Education, Changhua 50007, Taiwan, Email:

X. Zeng, Q. Gu, W. Dai, Y. Xie, X. Liu, G. Wu, Synthesis, 2021, 53, 2889-2896.

DOI: 10.1055/a-1488-4467

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Yb(OTf)3 catalyzes a regioselective hydroamination of ynamides with anilines and p-toluenesulfonamide to provide a diverse range of amidines with good functional group tolerance in good yields.

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Key Words

rare-earth salts, hydroamination, ynamides, amidines, amide

ID: J66-Y2021