Enantioselective Cobalt-Catalyzed Cascade Hydrosilylation and Hydroboration of Alkynes to Access Enantioenriched 1,1-Silylboryl Alkanes
Shengnan Jin, Kang Liu, Shuai Wang and Qiuling Song*
*Institute of Next Generation Matter Transformation, College of Material Sciences Engineering, Huaqiao University, Xiamen, Fujian 361021, China,
Email: qsong
hqu.edu.cn
S. Jin, K. Liu, S. Wang, Q. Song, J. Am. Chem. Soc., 2021, 143, 13124-13134.
DOI: 10.1021/jacs.1c04248
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Abstract
Enantioenriched 1,1-silylboryl alkanes are highly valued building blocks in asymmetric synthesis as well as medicinal chemistry. An enantioselective cobalt-catalyzed hydrosilylation/hydroboration cascade of terminal alkynes offers chemo-, regio-, and stereoselectivity exquisitely controlled by a single set of metal catalyst and ligand.
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proposed mechanism
Key Words
1,1-Silylboryl Alkanes, Multicomponent Reactions
ID: J48-Y2021
