Silver-Catalyzed Regioselective Synthesis of Highly Substituted 2-Trifluoromethyl Pyrroles
Wei Wu, Shunli Wen, Xinyu Zhang, Qi Lin* and Zhiqiang Weng*
*Fujian Engineering Research Center of New Chinese lacquer Material, Ocean College, Minjiang University, Fuzhou, 350108, China,
Email: linqi
mju.edu.cn, zwengmju.edu.cn
W. Wu, S. Wen, X. Zhang, Q. Lin, Z. Weng, Org. Lett., 2021, 23, 6352-6356.
DOI: 10.1021/acs.orglett.1c02136
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Abstract
A silver-catalyzed cyclization of vinyl azides with ethyl 4,4,4-trifluoro-3-oxobutanoate provides highly substituted 2-trifluoromethyl pyrroles. Various α-(heteo)aryl, alkyl, β-aryl, as well as α,β-disubstituted vinyl azides participate in this regioselective transformation.
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proposed mechanism
Key Words
ID: J54-Y2021
