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Mechanistic Investigation of Castagnoli-Cushman Multicomponent Reactions Leading to a Three-Component Synthesis of Dihydroisoquinolones

Sara Y. Howard, Michael J. Di Maso, Kristin Shimabukuro, Noah P. Burlow, Darlene Q. Tan, James C. Fettinger, Thomas C. Malig, Jason E. Hein and Jared T. Shaw*

*Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, United States, Email:

S. Y. Howard, M. J. Di Maso, K. Shimabukuro, N. P. Burlow, D. Q. Tan, J. C. Fettinger, T. C. Malig, J. E. Hein, J. T. Shaw, J. Org. Chem., 2021, 86, 11599-11607.

DOI: 10.1021/acs.joc.1c01163

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A 3CR of homophthalic anhydride, amines, and aldehydes provides dihydroisoquinolones in good yields and excellent diastereoselectivity.

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Key Words

dihydroisoquinolones, multicomponent reactions

ID: J42-Y2021