Mechanistic Investigation of Castagnoli-Cushman Multicomponent Reactions Leading to a Three-Component Synthesis of Dihydroisoquinolones
Sara Y. Howard, Michael J. Di Maso, Kristin Shimabukuro, Noah P. Burlow, Darlene Q. Tan, James C. Fettinger, Thomas C. Malig, Jason E. Hein and Jared T. Shaw*
*Department of Chemistry, University of California, One Shields Avenue, Davis, California 95616, United States,
Email: jtshaw
ucdavis.edu
S. Y. Howard, M. J. Di Maso, K. Shimabukuro, N. P. Burlow, D. Q. Tan, J. C. Fettinger, T. C. Malig, J. E. Hein, J. T. Shaw, J. Org. Chem., 2021, 86, 11599-11607.
DOI: 10.1021/acs.joc.1c01163
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Abstract
A 3CR of homophthalic anhydride, amines, and aldehydes provides dihydroisoquinolones in good yields and excellent diastereoselectivity.
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Key Words
dihydroisoquinolones, multicomponent reactions
ID: J42-Y2021
