Modular Synthesis of Polysubstituted Quinolin-3-amines by Oxidative Cyclization of 2-(2-Isocyanophenyl)acetonitriles with Organoboron Reagents
Shihui Wang, Jian Xu and Qiuling Song*
*College of Material Sciences Engineering at Huaqiao University, 668 Jimei Boulevard, Xiamen, Fujian 361021, China,
Email: qsong
hqu.edu.cn
S. Wang, J. Xu, Q. Song, Org. Lett., 2021, 23, 6789-6794.
DOI: 10.1021/acs.orglett.1c02373
see article for more reactions
Abstract
Mn(III) acetate as a mild one-electron oxidant promotes a radical process to construct polysubstituted quinolin-3-amines from 2-(2-isocyanophenyl)acetonitriles and organoboron reagents. This method is practical, mild, efficient, and offers good functional group compatibility.
see article for more examples
Key Words
ID: J54-Y2021
