Organic Chemistry Portal



Transition-Metal-Free Alkylation and Acylation of Benzoxazinones with 1,4-Dihydropyridines

Youjung Byun, Junghyea Moon, Won An, Neeraj Kumar Mishra, Hyung Sik Kim, Prithwish Ghosh* and In Su Kim*

*School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea, Email:,

Y. Byun, J. Moon, W. An, N. K. Mishra, H. S. Kim, P. Ghosh, I. S. Kim, J. Org. Chem., 2021, 86, 12247-12256.

DOI: 10.1021/acs.joc.1c01558

see article for more reactions


A transition-metal-free alkylation and acylation of C(sp2)-H bonds in biologically relevant 2-benzoxazinones with 1,4-dihydropyridines offers excellent functional group compatibility and a broad substrate scope.

see article for more examples

proposed mechanism

Key Words

2-benzoxazinones, sodium peroxydisulfate

ID: J42-Y2021