Palladium/Brønsted-Acid-Catalyzed Diastereoselective Cyclization with Chiral Sulfinamides as Nucleophiles
Chun-Tai Hung, Chun-Wei Lu, Shi-Han Huang, Yin-Feng Lu, Hsiang-Chi Chou and Cheng-Che Tsai*
*Department of Chemistry, Tunghai University, Taichung City 40704, Taiwan,
Email: chengchetsai
thu.edu.tw
C.-T. Hung, C.-W. Lu, S.-H. Huang, Y.-F. Lu, H.-C. Chou, C.-C. Tsai, J. Org. Chem., 2021, 86, 12354-12366.
DOI: 10.1021/acs.joc.1c01301
see article for more reactions
Abstract
Synergistic palladium and Brønsted acid catalysis enables a diastereoselective cyclization of chiral sulfinamides as nucleophiles to provide chiral isoindolines with good yields and high diastereoselectivities.
see article for more examples
Key Words
ID: J42-Y2021
