Bisulfite Addition Compounds as Substrates for Reductive Aminations in Water
Xiaohan Li, Karthik S. Iyer, Ruchita R. Thakore, David K. Leahy, J. Daniel Bailey* and Bruce H. Lipshutz*
*Takeda Pharmaceuticals, 35 Landsdowne Street, Cambridge, Massachusetts 02139; University of California, Santa Barbara, California
93106, USA,
Email: Dan.Bailey
Takeda.com, lipshutzchem.ucsb.edu
X. Li, K. S. Iyer, R. R. Thakore, D. K. Leahy, J. D. Bailey, B. H. Lipshutz, Org. Lett., 2021, 23, 7205-7208.
DOI: 10.1021/acs.orglett.1c02604
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Abstract
Reductive aminations of shelf-stable bisulfite addition compounds of aldehydes can be run under aqueous micellar catalysis conditions with readily available α-picolineborane as the stoichiometric hydride source. Recycling of the aqueous reaction medium is easily accomplished.
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TPGS-750-M
Key Words
reductive amination, α-picolineborane, green chemistry
ID: J54-Y2021
