Nickel-Catalyzed Multicomponent Coupling: Synthesis of α-Chiral Ketones by Reductive Hydrocarbonylation of Alkenes
Jian Chen and Shaolin Zhu*
*Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China,
Email: shaolinzhu
nju.edu.cn
J. Chen, S. Zhu, J. Am. Chem. Soc., 2021, 143, 14089-14096.
DOI: 10.1021/jacs.1c07851
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Abstract
A nickel-catalyzed, multicomponent regio- and enantioselective hydroformylation and carbonylation using chloroformate as a safe CO source provides a wide variety of unsymmetrical dialkyl ketones bearing a functionalized α-stereocenter, including enantioenriched chiral α-aryl ketones and α-amino ketones.
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Key Words
Hydrocarbonylation, Ketones, Multicomponent Reactions, DEMS
ID: J48-Y2021
