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Nickel-Catalyzed Multicomponent Coupling: Synthesis of α-Chiral Ketones by Reductive Hydrocarbonylation of Alkenes

Jian Chen and Shaolin Zhu*

*Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China, Email:

J. Chen, S. Zhu, J. Am. Chem. Soc., 2021, 143, 14089-14096.

DOI: 10.1021/jacs.1c07851

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A nickel-catalyzed, multicomponent regio- and enantioselective hydroformylation and carbonylation using chloroformate as a safe CO source provides a wide variety of unsymmetrical dialkyl ketones bearing a functionalized α-stereocenter, including enantioenriched chiral α-aryl ketones and α-amino ketones.

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Key Words

Hydrocarbonylation, Ketones, Multicomponent Reactions, DEMS

ID: J48-Y2021