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Asymmetric Domino Heck Arylation and Alkylation of Nonconjugated Dienes: Double C–F···Sodium Attractive Noncovalent Interaction

Daoyong Zhu, Wenqiang Xu, Maoping Pu, Yun-Dong Wu, Yonggui Robin Chi and Jianrong Steve Zhou*

*School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Room F312, 2199 Lishui Road, Nanshan District, Shenzhen 518055, China, Email:

D. Zhu, W. Xu, M. Pu, Y.-D. Wu, Y. R. Chi, J. S. Zhou, Org. Lett., 2021, 23, 7064-7068.

DOI: 10.1021/acs.orglett.1c02457

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Palladium catalyzes a domino Heck arylation and alkylation of nonconjugated cyclohexadienes to produce trans isomers of disubstituted cyclohexenes in exceptionally high enantiomeric ratios.

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Key Words

cyclohexenes, Heck reaction, multicomponent reactions

ID: J54-Y2021