Unactivated Alkyl Chloride Reactivity in Excited-State Palladium Catalysis

Krishnamoorthy Muralirajan*, Rajesh Kancherla, Aidana Gimnkhan and Magnus Rueping*

*KAUST Catalysis Center (KCC), King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia, Email: muralirajan.krishnamoorthykaust.edu.sa, magnus.ruepingkaust.edu.sa

K. Muralirajan, R. Kancherla, A. Gimnkhan, M. Rueping, Org. Lett., 2021, 23, 6905-6910.

DOI: 10.1021/acs.orglett.1c02467

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Abstract

Excited-state palladium catalysis is an efficient process for the alkylation of diverse organic compounds via the generation of alkyl radicals from alkyl halides. An excited-state palladium-complex catalyzes the synthesis of oxindoles and isoquinolinediones via alkylation/annulation reaction with unactivated alkyl chlorides even at room temperature.

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proposed mechanism

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Key Words

oxindoles, photochemistry

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ID: J54-Y2021