Benzyne-Mediated Esterification Reaction
Jinlong Zhao, Jiarong Shi* and Yang Li*
*School of Chemistry and Chemical Engineering, Chongqing University, 174 Shazheng Street, Chongqing, P. R. China, 400030, Email: 1138416789qq.com, y.licqu.edu.cn
J. Zhao, J. Shi, Y. Li, Org. Lett., 2021, 23, 7274-7278.
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A benzyne-mediated esterification of carboxylic acids and alcohols provides products under mild conditions via a selective nucleophilic addition of carboxylic acid to benzyne in the presence of alcohol followed by a transesterification with alcohol. Benzyne can also be used to promote lactonization and amidation reactions.
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proposed reaction pathway