Iron-Catalyzed Alkyne-Based Multicomponent Synthesis of Pyrimidines under Air
Rakesh Mondal, Gargi Chakraborty, Amit Kumar Guin, Susmita Sarkar and Nanda D. Paul*
*Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Botanic Garden, Howrah 711103, India,
Email: ndpaul2014
chem.iiests.ac.in
R. Mondal, G. Chakraborty, A. K. Guin, S. Sarkar, N. D. Paul, J. Org. Chem., 2021, 86, 13186-13197.
DOI: 10.1021/acs.joc.1c00867
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Abstract
An easy to prepare, tridentate arylazo pincer iron complex catalyzes an eco-friendly construction of trisubstituted pyrimidines under mild aerobic conditions via dehydrogenative functionalization of alcohols with alkynes and amidines.
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proposed mechanism
Key Words
multicomponent reactions, pyrimidines, oxygen
ID: J42-Y2021
